Floppy-eared puppies are the first test-tube dogs. They're also adorable.

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The World's First In Vitro Puppies Prove Science Can Be Adorable

A team of veterinarians, scientists and lab workers gathered around a surrogate hound and watched her give birth to seven half-pound puppies, the first dogs ever conceived in a test tube.

"We each took a puppy and rubbed it with a little towel and when it started to squiggle and cry, we knew we had success," said Dr. Alexander Travis, who runs the lab at the Baker Institute for Animal Health at Cornell University's College of Veterinary Medicine in Ithaca, New York.

"Their eyes were closed. They were just adorable, cute, with smooshed-in faces. We checked them to make sure they looked normal and were all breathing," he said.

See the groundbreaking pups:

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World's first IVF puppies
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Floppy-eared puppies are the first test-tube dogs. They're also adorable.
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The puppies born July 10 are a mix of beagle, Labrador and cocker spaniel and are now healthy 5-month-olds, Travis said. All but one female were adopted. She's being kept by the lab to have her own litter.

The lab kept track of the puppies by painting their nails with different color polish. Travis adopted two, still known by their nail polish names, Red and Green.

In vitro fertilization, the process of fertilizing an egg with sperm outside the body, is widely used to assist human reproduction these days. The first human birth from IVF took place in 1978.

But IVF efforts with dogs repeatedly failed until now, according to Dr. Pierre Comizzoli, a reproductive physiologist for the Smithsonian Conservation Biology Institute in Front Royal, Virginia, which works with Cornell.

"The biology of the dog is really, really different than humans," Comizzoli said. Dog pregnancies last only two months and females go into heat just once or twice a year, releasing immature eggs instead of mature eggs needed for IVF.

An earlier experiment at Cornell helped pave the way. In 2013 at Cornell, Klondike became the first puppy born from a frozen embryo. Klondike's beagle mother was fertilized using artificial insemination. Her embryos were collected, frozen and implanted in Klondike's surrogate mother.

Comizzoli described the birth of the seven puppies "as a huge breakthrough."

A paper describing the Cornell litter as "the first live births from in vitro fertilized embryos in the dog" appeared Tuesday in the PLOS ONE journal. The lead author, Smithsonian Conservation Biology Institute doctoral fellow Jennifer Nagashima, said IVF technology in dogs could prove useful in everything from conserving endangered species to removing "deleterious traits from breeds," with research potentially applicable to "models for human disease" as well.

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Also see these adorable animal pals:

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Unlikely best animal friends
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Floppy-eared puppies are the first test-tube dogs. They're also adorable.
The animals usually hang out with their own species. But recently, zoo keepers at Busch Gardens noticed the unlikely pair that just can't seem to get enough of one another.
The tiger and orangutan babies, which would never be together in the wild, have become inseparable playmates after they were abandoned by their mothers.
A farm worker holds a piglet and two of the three tiger cubs abandoned by their mother.
The odd couple got together when Kenya Wildlife Service rangers rescued the baby hippo in the sea off Malindi after the Asian tsumani reached the Kenyan shore and separated the calf from its mother.
Mildred, a mallard duck became the foster mother of these kittens abandoned by their mother, even sleeping with them in this basket.
The baby kitten sits on the Beagle's back trying to get his attention.
The three play at Noah Ark Rehabilitation Centre after their rescue in 2001.
They go for walks together and play together until they fall asleep on the sofa together.
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