Pope in Cuba begs Colombia, rebels to end conflict

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US-Cuba Relations Remains Big Focus as Pope Visits Havana

HAVANA (AP) -- Pope Francis begged the Colombian government and rebels on Sunday to end South America's longest-running conflict, saying they simply cannot allow ongoing peace talks to fail.

Fresh off his personal appeal to the U.S. and Cuban leaders to end their half-century of estrangement, Francis issued his plea to Colombia's warring factions from Revolution Plaza at the end of his Sunday Mass. Cuba has hosted peace talks for more than two years between the Revolutionary Armed Forces of Colombia and representatives of Bogota.

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Pope Francis in Havana, Cuba - 9/20
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Pope in Cuba begs Colombia, rebels to end conflict
Pope Francis arrives at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / LUIS ACOSTA (Photo credit should read LUIS ACOSTA/AFP/Getty Images)
Cubans wait for catch a glimpse of Pope Francis as he arrives at Revolution Square in Havana, on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. AFP PHOTO / Rodrigo ARANGUA (Photo credit should read RODRIGO ARANGUA/AFP/Getty Images)
Pope Francis arrives at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / ADALBERTO ROQUE (Photo credit should read ADALBERTO ROQUE/AFP/Getty Images)
Cubans gather at Revolution Square in Havana for a mass with Pope Francis, on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Pope Francis arrives at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
A woman is carried away on a stretcher by Red Cross workers after she fainted during a Mass celebrated by Pope Francis at Revolution Plaza in Havana, Cuba, Sunday Sept. 20, 2015. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (AP Photo/Ramon Espinosa)
A religious man with a Mexican flag waits for the arrival of Pope Francis at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Faithful attend Mass celebrated by Pope Francis at Revolution Plaza in Havana, Cuba, Sunday Sept. 20, 2015. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (AP Photo/Ramon Espinosa)
Cuban President Raul Castro (C) speaks with other authorities and their relatives as they wait for the arrival of Pope Francis at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Pope Francis arrives at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / ADALBERTO ROQUE (Photo credit should read ADALBERTO ROQUE/AFP/Getty Images)
Pope Francis arrives at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / ADALBERTO ROQUE (Photo credit should read ADALBERTO ROQUE/AFP/Getty Images)
Pope Francis arrives at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / ADALBERTO ROQUE (Photo credit should read ADALBERTO ROQUE/AFP/Getty Images)
Pope Francis arrives for Mass at Revolution Plaza in Havana, Cuba, Sunday, Sept. 20, 2015. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (AP Photo/Ramon Espinosa)
Faithful wait for the arrival of Pope Francis for a Mass in Revolution Plaza in Havana, Cuba, Sunday, Sept. 20, 2015. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. The photo of the pope reads in Spanish: "Welcome!" (AP Photo/Enric Marti)
Pope Francis kisses a girl as he arrives at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / RODRIGO ARANGUA (Photo credit should read RODRIGO ARANGUA/AFP/Getty Images)
Pope Francis arrives at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / RODRIGO ARANGUA (Photo credit should read RODRIGO ARANGUA/AFP/Getty Images)
People cheer as Pope Francis arrives at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / RODRIGO ARANGUA (Photo credit should read RODRIGO ARANGUA/AFP/Getty Images)
Pope Francis gives mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Pope Francis arrives at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / RODRIGO ARANGUA (Photo credit should read RODRIGO ARANGUA/AFP/Getty Images)
Pope Francis gives mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Pope Francis (L) gives mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / YAMIL LAGE (Photo credit should read YAMIL LAGE/AFP/Getty Images)
Pope Francis gives mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / YAMIL LAGE (Photo credit should read YAMIL LAGE/AFP/Getty Images)
Pope Francis (C) walks to the altar arrives to give mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Pope Francis (L) gives mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / YAMIL LAGE (Photo credit should read YAMIL LAGE/AFP/Getty Images)
Pope Francis (C) gives mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / LUIS ACOSTA (Photo credit should read LUIS ACOSTA/AFP/Getty Images)
A statue of Jesus stands in Revolution Square, where a statue of revolutionary hero Ernesto "Che" Guevera decorates a nearby government building in Havana, Cuba, Sunday, Sept. 20, 2015, as Pope Francis arrives to celebrate Mass. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (Tony Gentile/POOL via AP)
Pope Francis walks to the altar as he arrives to celebrate Mass in Revolution Square in Havana, Cuba, Sunday, Sept. 20, 2015. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (Tony Gentile/POOL via AP)
A chorus sings as Pope Francis arrives for Mass at Revolution Plaza in Havana, Cuba, Sunday, Sept. 20, 2015. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (AP Photo/Alessandra Tarantino)
Pope Francis is helped to the altar as he arrives to celebrate Mass in Revolution Square in Havana, Cuba, Sunday, Sept. 20, 2015, where a sculpture of revolutionary hero Ernesto "Che" Guevara decorates a nearby government building. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (Tony Gentile/POOL via AP)
A woman prays during a Mass celebrated by Pope Francis at Revolution Plaza in Havana, Cuba, Sunday Sept. 20, 2015. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (AP Photo/Ramon Espinosa)
People attend the first mass of Pope Francis on his visit to Cuba, at Havana's Revolution Square on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Pope Francis (2-L) gives mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / LUIS ACOSTA (Photo credit should read LUIS ACOSTA/AFP/Getty Images)
People gather at Revolution Square for Pope Francis's mass on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. Across from the square is a portrait of revolutionary leader Camilo Cienfuegos. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
HAVANA, CUBA - SEPTEMBER 20: Pope Francis performs Mass on September 20, 2015 in Revolution Square in Havana, Cuba. Pope Francis is on the first full day of his three day visit to Cuba where he will meet President Raul Castro and hold Mass in Revolution Square before travelling to Holguin, Santiago de Cuba and El Cobre then onwards to the United States. (Photo by Carl Court/Getty Images)
General view of Havana's Revolution Square as Pope Francis gives the first mass of his visit to Cuba, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Pope Francis gives mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / RODRIGO ARANGUA (Photo credit should read RODRIGO ARANGUA/AFP/Getty Images)
Cuban President Raul Castro and Argentine President Cristina Fernandez de Kirchner (R) wait for the arrival of Pope Francis at Revolution Square in Havana on September 20, 2015. Pope Francis will give mass on Revolution Square, the biggest event of his trip to Cuba, with nearly a million people expected to attend. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
People wait for the start of the mass to be officiated by Pope Francis at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / YAMIL LAGE (Photo credit should read YAMIL LAGE/AFP/Getty Images)
Religious men and faithfuls attend Pope Francis' mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / ADALBERTO ROQUE (Photo credit should read ADALBERTO ROQUE/AFP/Getty Images)
A religious woman waits for the start of the mass to be officiated by Pope Francis at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Pope Francis gives mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / RODRIGO ARANGUA (Photo credit should read RODRIGO ARANGUA/AFP/Getty Images)
People cheer as Pope Francis arrives at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / ADALBERTO ROQUE (Photo credit should read ADALBERTO ROQUE/AFP/Getty Images)
Pope Francis gives mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Pope Francis arrives at Revolution Square in Havana to give mass on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Pope Francis arrives at Revolution Square in Havana to give mass on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
Pope Francis gives mass at Revolution Square in Havana, on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. The pontiff's eight-day tour will also take him to the United States. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
A soldier stands guard as people gather at Revolution Square for Pope Francis's mass on September 20, 2015. Pope Francis greeted massive crowds of fans and Catholic faithful Sunday as he arrived in his popemobile to give mass on Havana's iconic Revolution Square, the highlight of his trip to Cuba. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)
A woman shades herself from the sun at the end of Mass, celebrated by Pope Francis in Revolution Plaza in Havana, Cuba, Sunday, Sept. 20, 2015. Pope Francis urged Cubans to care for one another, and not judge each other, as he opened his visit to the country amid great hopes that the key role he played in bringing about detente with the U.S. will result in changes on the island. (AP Photo/Desmond Boylan)
A priest gives Holy Communion to faithful during Mass celebrated by Pope Francis at Revolution Plaza in Havana, Cuba, Sunday Sept. 20, 2015. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (AP Photo/Desmond Boylan)
A nun holds an Argentine flag during Mass celebrated by Pope Francis, who's from Argentina, in Revolution Plaza in Havana, Cuba, Sunday, Sept. 20, 2015, where a sculpture of revolutionary hero Ernesto "Che" Guevara decorates a government building. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (AP Photo/Enric Marti)
Cuba's Cardinal Jaime Ortega, right, stands behind Pope Francis in the popemobile as they arrive for Mass at Revolution Plaza in Havana, Cuba, Sunday, Sept. 20, 2015. During Mass Sunday, Ortega thanked the pope for his work promoting detente between Havana and Washington and called for reconciliation between Cubans living on the island and elsewhere. Ortega was among many priests sent to military-run agricultural camps in the 1960s after Fidel Castro declared Cuba to be socialist and accused prominent Catholics of trying to topple him. (Ismael Francisco/Cubadebate Via AP)
A man looks out over Revolution Square as Pope Francis celebrates Mass in Havana, Cuba, Sunday, Sept. 20, 2015, where sculptures of revolutionary heroes Ernesto "Che" Guevara, left, and Camilo Cienfuegos decorate government buildings. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (AP Photo/Alessandra Tarantino)
Photographers aim their cameras at Pope Francis as he celebrates Mass at Revolution Plaza in Havana, Cuba, Sunday, Sept. 20, 2015, where a sculpture of revolutionary hero Ernesto "Che" Guevara and a Cuban flag decorate government buildings. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (AP Photo/Desmond Boylan)
People attend Mass celebrated by Pope Francis at Revolution Plaza in Havana, Cuba, Sunday, Sept. 20, 2015. Pope Francis opens his first full day in Cuba on Sunday with what normally would be the culminating highlight of a papal visit: Mass before hundreds of thousands of people in Havana's Revolution Plaza. (AP Photo/Desmond Boylan)
HAVANA, CUBA - SEPTEMBER 20: People leave after Pope Francis performs Mass on September 20, 2015 in Revolution Square in Havana, Cuba. Pope Francis is on the first full day of his three day visit to Cuba where he will meet President Raul Castro and hold Mass in Revolution Square before travelling to Holguin, Santiago de Cuba and El Cobre then onwards to the United States. (Photo by Carlos Becerra/Anadolu Agency/Getty Images)
HAVANA, CUBA - SEPTEMBER 20: People look on as Pope Francis performs Mass on September 20, 2015 in Revolution Square in Havana, Cuba. Pope Francis is on the first full day of his three day visit to Cuba where he will meet President Raul Castro and hold Mass in Revolution Square before travelling to Holguin, Santiago de Cuba and El Cobre then onwards to the United States. (Photo by Carlos Becerra/Anadolu Agency/Getty Images)
HAVANA, CUBA - SEPTEMBER 20: People look on as Pope Francis performs Mass on September 20, 2015 in Revolution Square in Havana, Cuba. Pope Francis is on the first full day of his three day visit to Cuba where he will meet President Raul Castro and hold Mass in Revolution Square before travelling to Holguin, Santiago de Cuba and El Cobre then onwards to the United States. (Photo by Carlos Becerra/Anadolu Agency/Getty Images)
HAVANA, CUBA - SEPTEMBER 20: People look on as Pope Francis performs Mass on September 20, 2015 in Revolution Square in Havana, Cuba. Pope Francis is on the first full day of his three day visit to Cuba where he will meet President Raul Castro and hold Mass in Revolution Square before travelling to Holguin, Santiago de Cuba and El Cobre then onwards to the United States. (Photo by Carlos Becerra/Anadolu Agency/Getty Images)
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Francis said the talks face a "crucial" moment.

"May the blood shed by thousands of innocent people during long decades of armed conflict" sustain efforts to find a definitive peace, he said. "Please, we do not have the right to allow ourselves yet another failure on this path of peace and reconciliation."

Colombian President Juan Manuel Santos, who has pushed the talks, issued a tweet in response to thank the pope "for your permanent prayers. We will continue on the road of peace and reconciliation."

In his remarks, Francie added on a word of gratitude to President Raul Castro for his efforts to assist the negotiations; the appeal was followed by a round of applause from the crowd.

In more than two years of negotiations, rebel and government negotiators have reached tentative agreements on land reform, how to jointly combat drug trafficking and the future role in politics for guerrillas that lay down their weapons. The rebel movement, known as the FARC, in recent months also has largely adhered to a unilateral cease-fire, prompting the government to suspend the aerial bombing of guerrilla camps.

But despite the advances, a number of obstacles remain to ending the half-century conflict, chief among them the thorny issue of whether rebel commanders behind scores of human rights abuses will be punished with prison time.

Watch more coverage:

Pope Francis Arrives in Cuba Ahead of US Visit

Polls indicate most Colombians support a negotiated settlement but have increasingly little faith the FARC will deliver on its promises.

The FARC leader known by his alias Ivan Marquez said in August that the rebels wanted to meet with the pope during his visit to Cuba, saying it would help reinforce the efforts of millions of Colombians.

But the Vatican made clear no such meeting would take place, given Francis wanted his visit to focus on Cuba. His appeal Sunday appeared to be a way to address the conflict without derailing his overall Cuban focus.

See more of the preparation of Pope Francis in the US:

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U.S. preps for Pope Francis' visit
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Pope in Cuba begs Colombia, rebels to end conflict
Father Dave Fitz-Patrick stands left as children gather in the playground with a life-size cutout of Pope Francis at Our Lady of Victory Catholic School in Washington, Tuesday, Sept. 8, 2015, during a media availability to show preparations for Pope Francis' visit to Washington. (AP Photo/Carolyn Kaster)
NEW YORK, NY - SEPTEMBER 21: A portrait of Pope Franics sits in a window near Our Lady Queen of Angels School in East Harlem where Pope Francis is scheduled to visit on September 21, 2015 in New York City. The Pope will be making his first trip to the United States on a three-city, five-day tour that will begin in Washington on September 22, then travel to New York City and Philadelphia. The Pope will depart on September 27. (Photo by Spencer Platt/Getty Images)
Poor Clares nuns Sister Maria Eden, left, and Sister Thereza share a laugh as they make altar bread also known as communion wafers, Tuesday, Sept. 8, 2015, at the Monastery of Saint Clare in Langhorne, Pa. The nuns are helping to supply wafers for the scheduled Mass being celebrated by Pope Francis on Sept. 27. (AP Photo/Matt Rourke)
Sign painters work on a portrait of Pope Francis on the side of a New York City office building, Sunday, Aug. 30, 2015. The Pope visits the U.S. beginning Sept. 22 with stops in Washington D.C., New York and Philadelphia. (AP Photo/Mark Lennihan)
Workers set up rows of chairs in preparation of the Pope's visit at the Basilica of the National Shrine of the Immaculate Conception Monday, Sept. 21, 2015, in Washington. Pope Francis will celebrate Mass Wednesday at the basilica, the largest Catholic church in the United States and North America, with a crowd of about 30,000. (AP Photo/David Goldman)
A man buys a souvenir medal with a picture of Pope Francis at a machine inside the Saint Patrick Cathedral in New York on August 28, 2015. Pope Francis will visit the US on September 22-27, stopping in Washington, DC, New York, and Philadelphia. AFP PHOTO/JEWEL SAMAD (Photo credit should read JEWEL SAMAD/AFP/Getty Images)
Bobble head figures of Pope Francis are displayed at the Catholic Information Center (CIC) in Washington, Monday, Sept. 21, 2015. The figures are being sold at the CIC but are currently sold-out but the bookstore expects new inventory of the popular item to arrive in time for Pope's visit to Washington starting Tuesday. (AP Photo/Pablo Martinez Monsivais)
Rosaries with the image of Pope Francis are selling at the Catholic University of America, Basilica of the National Shrine of the Immaculate Conception, gift shop on September 3, 2015, prior to the visit to of the Pope on September 23, 2015. AFP PHOTO/PAUL J. RICHARDS (Photo credit should read PAUL J. RICHARDS/AFP/Getty Images)
Burler Carmen Martinez works on a carpet made for Pope Francis' scheduled visit to Philadelphia, Thursday, Sept. 10, 2015, at the Langhorne Carpet Company in Penndel, Pa. It features a gold border with a medallion design inspired by stained glass windows in the city's cathedral. (AP Photo/Matt Rourke)
A man shows a medal he bought with a picture of Pope Francis from a machine inside the Saint Patrick Cathedral in New York on August 28, 2015. Pope Francis will visit the US on September 22-27, stopping in Washington, DC, New York, and Philadelphia. AFP PHOTO/JEWEL SAMAD (Photo credit should read JEWEL SAMAD/AFP/Getty Images)
A sign painter outlines the Pope's nose on the side of a New York City office building, Thursday, Aug. 27, 2015. Pope Francis visits the U.S. beginning Sept. 22 with stops in Washington D.C., New York and Philadelphia. (AP Photo/Mark Lennihan)
Poor Clares nun Sister Maria Eden packs for shipment altar bread also known as communion wafers, Tuesday, Sept. 8, 2015, at the Monastery of Saint Clare in Langhorne, Pa. The nuns are helping to supply wafers for the scheduled Mass being celebrated by Pope Francis on Sept. 27. (AP Photo/Matt Rourke)
Children play in the playground with a life-size cutout of Pope Francis at Our Lady of Victory Catholic School in Washington, Tuesday, Sept. 8, 2015, during a media availability to show preparations for Pope Francis' visit to Washington. (AP Photo/Carolyn Kaster)
A worker walks through rows of chairs being set up in preparation of the Pope's visit at the Basilica of the National Shrine of the Immaculate Conception Monday, Sept. 21, 2015, in Washington. Pope Francis will celebrate Mass Wednesday at the basilica, the largest Catholic church in the United States and North America, with a crowd of about 30,000. (AP Photo/David Goldman)
A pope-mobile souvenir sits on a shelf at the Basilica of the National Shrine of the Immaculate Conception Monday, Sept. 21, 2015, in Washington. Pope Francis will celebrate Mass Wednesday at the basilica, the largest Catholic church in the United States and North America, with a crowd of about 30,000. (AP Photo/David Goldman)
Inmates Rameen Perrin, left, and Evan Davis working a chair carved out of walnut for Pope Francis to use during his planned visit to the prison next month, Monday, Aug. 24, 2015, at the Curran-Fromhold Correctional Facility in Philadelphia. Francis plans to meet on Sept. 27 with about 100 inmates and some of their relatives during a two-day trip to the city. (AP Photo/Michael Perez)
Inmate Evan Davis works on a chair carved out of walnut for Pope Francis to use during his planned visit to the prison next month, Monday, Aug. 24, 2015, at the Curran-Fromhold Correctional Facility in Philadelphia. Francis plans to meet on Sept. 27 with about 100 inmates and some of their relatives during a two-day trip to the city. (AP Photo/Michael Perez)
Head carpenter Carlos Hernandez points to renderings of the altar that Pope Francis will use during his Mass in Washington next month, Monday, Aug. 17, 2015, at Carriage Hill Cabinets in Frederick, Md. Construction of the papal furnishings for Pope's outdoor Mass at the Basilica of the National Shrine of the Immaculate Conception, which will take place on Wednesday, Sept. 23, 2015, are being completed in a suburb north of Washington DC. (AP Photo/Pablo Martinez Monsivais)
Deacon David Cahoon, left, from the Archdiocese of Washington and professional carpenter, gives a television interview as head carpenter Carlos Hernandez, center, lifts up a portion of the altar that Pope Francis will use during his Mass in Washington next month, as work continues at , Monday, Aug. 17, 2015, at Carriage Hill Cabinets in Frederick, Md. Construction of the papal furnishings for Pope's outdoor Mass at the Basilica of the National Shrine of the Immaculate Conception, which will take place on Wednesday, Sept. 23, 2015, are taking shape in a suburb north of Washington DC. (AP Photo/Pablo Martinez Monsivais)
Head carpenter Carlos Hernandez works on the altar that Pope Francis will use during his Mass in Washington next month, Monday, Aug. 17, 2015, at Carriage Hill Cabinets in Frederick, Md. Construction of the papal furnishings for Pope's outdoor Mass at the Basilica of the National Shrine of the Immaculate Conception, which will take place on Wednesday, Sept. 23, 2015, are taking shape in suburb north of Washington DC. (AP Photo/Pablo Martinez Monsivais)
Mary Sisti, a vetted volunteer for next month's visit to Philadelphia by Pope Francis, poses for a photo near her home Wednesday, Aug. 19, 2015, in Princeton, N.J. About 10,000 volunteers will be on the ground in Philadelphia for the upcoming World Meeting of Families and papal visit. And every one of those unpaid aides will have undergone a criminal and professional background check at a cost of $28 each. Sisti paid the full cost of her background check, noting that the $28 fee “was the least I could do. It’s a small contribution and being put to good use for my own purposes.” (AP Photo/Mel Evans)
Displayed is an event area map for Pope Francis' scheduled visit to Philadelphia, during Mayor Michael Nutter's news conference Thursday, Aug. 13, 2015, in Philadelphia. The U.S. Secret Service will turn large swaths of downtown Philadelphia into vehicle-free security zones with fenced inside areas during Pope Francis' visit next month. (AP Photo/Matt Rourke)
A statue and other items related to Pope Francis are for sale at the gift shop at The Basilica of the National Shrine of the Immaculate Conception on August 20, 2015 in Washington, DC. Pope Francis will be celebrating Mass at the National Shrine on September 23, 2015, where he will canonize Junipero Serra, the Spanish missionary who introduced Christianity to California in the 18th century. AFP PHOTO/MANDEL NGAN (Photo credit should read MANDEL NGAN/AFP/Getty Images)
Pope Francis bobble heads are displayed at a souvenir store in Washington, DC on August 27, 2015. Pope Francis will travel to the United States from September 22-27, stopping in Washington, DC, New York, and Philadelphia. AFP PHOTO/ ANDREW CABALLERO-REYNOLDS (Photo credit should read Andrew Caballero-Reynolds/AFP/Getty Images)
A woman poses for a photo next to a cut-out figure of Pope Francis at The Basilica of the National Shrine of the Immaculate Conception on August 20, 2015 in Washington, DC. Pope Francis will be celebrating Mass at the National Shrine on September 23, 2015, where he will canonize Junipero Serra, the Spanish missionary who introduced Christianity to California in the 18th century. AFP PHOTO/MANDEL NGAN (Photo credit should read MANDEL NGAN/AFP/Getty Images)
Noah Rodriguez, 4th grade, answers questions from a reporter in the gym during a media preview at Our Lady Queen of Angels School on August 20, 2015 in New York. Allison will be among 24 children, who attend Catholic schools in New York, who will meet with Pope Francis during his September 25, 2015 visit to New York. AFP PHOTO/DON EMMERT (Photo credit should read DON EMMERT/AFP/Getty Images)
Allison Reyes-Rodriguez, 3rd grade, answers questions from reporters during a media preview at Our Lady Queen of Angels School on August 20, 2015 in New York. Allison will be among 24 children, who attend Catholic schools in New York, who will meet with Pope Francis during his September 25, 2015 visit to New York. AFP PHOTO/DON EMMERT (Photo credit should read DON EMMERT/AFP/Getty Images)
The Basilica of the National Shrine of the Immaculate Conception is seen on August 20, 2015 in Washington, DC. Pope Francis will be celebrating Mass at the National Shrine on September 23, 2015, where he will canonize Junipero Serra, the Spanish missionary who introduced Christianity to California in the 18th century. AFP PHOTO/MANDEL NGAN (Photo credit should read MANDEL NGAN/AFP/Getty Images)
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