George Clooney on anniversary plans and wife Amal's stressful job: 'She's a grown woman'

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How George Clooney and Amal Will Be Spending Their 1-Year Anniversary

George Clooney is gearing up to celebrate his first wedding anniversary with wife Amal on September 27, but it turns out the busy actor and producer already has a work obligation on the big day!

"Unfortunately, I have to speak at Jerry Weintraub's memorial," Clooney wryly told ET at the Toronto International Film Festival on Friday. "This is his last producorial way of screwing me over, that on my anniversary, I have to go to his memorial."

WATCH: George Clooney Reveals Why He Fell in Love With Amal

The actor and producer, who was in Toronto promoting his latest film Our Brand is Crisis, opened up about his wife Amal, an international human rights attorney, who is currently representing deposed Maldives president Mohamed Nasheed in Sri Lanka. It's a stressful job that can sometimes put her in harm's way, and her husband openly admits to worrying about Amal's wellbeing.

"She's a grown woman with her own career," the Tomorrowland star conceded. "It's tough when they're stabbing her co-counselor [defense lawyer Mahfooz Saeed] in the head a couple days before she gets there. It's a little nerve wracking. But she's doing the right thing and she's doing it for the right reasons."

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George Clooney on anniversary plans and wife Amal's stressful job: 'She's a grown woman'
FLORENCE, ITALY - SEPTEMBER 07: (EDITORS NOTE: This image was processed using digital filters) George Clooney (R) and Amal Alamuddin attend the Celebrity Fight Night gala celebrating Celebrity Fight Night In Italy benefitting The Andrea Bocelli Foundation and The Muhammad Ali Parkinson Center on September 7, 2014 in Florence, Italy. (Photo by Rachel Murray/Getty Images for Celebrity Fight Night)
George Clooney, right, and Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world’s most romantic settings. (AP Photo/Luca Bruno)
US actor George Clooney arrives at the Aman hotel on September 27, 2014 in Venice where Clooney and British fiancee, Amal Alamuddin celebrate their wedding. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
Amal Alamuddin, fiancee of George Clooney, arrives in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world’s most romantic settings. (AP Photo/Luca Bruno)
Guests leave Palazzo Papadopoli Aman hotel on September 27, 2014 in Venice where US actor George Clooney and British fiancee, Amal Alamuddin celebrate their wedding. Hollywood heartthrob George Clooney and Lebanese-British lawyer Amal Alamuddin married in Venice and looked set to party the night away with their A-list friends in one of the most high-profile celebrity weddings in years. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read Pierre Teyssot/AFP/Getty Images)
VENICE, ITALY - SEPTEMBER 27: Actor George Clooney sighting at Canal Grande on September 27, 2014 in Venice, Italy. (Photo by Ernesto Ruscio/GC Images)
US actor Bill Murray (C) arrives with guests at Palazzo Papadopoli, Hotel Aman, on September 27, 2014 in Venice where Clooney and British fiancee, Amal Alamuddin celebrate their wedding. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read PIERRE TEYSSOT/AFP/Getty Images)
Singer Bono (R) arrives at Palazzo Papadopoli, Hotel Aman, on September 27, 2014 in Venice where Clooney and British fiancee, Amal Alamuddin celebrate their wedding. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read PIERRE TEYSSOT/AFP/Getty Images)
Guests attend a cocktail at the Cipriani hotel on September 27, 2014 in Venice where US actor George Clooney and British fiancee, Amal Alamuddin celebrate their wedding. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
Model Cindy Crawford (C) arrives at Palazzo Papadopoli, Hotel Aman, on a taxi boat on September 27, 2014 in Venice where Clooney and British fiancee, Amal Alamuddin celebrate their wedding. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read PIERRE TEYSSOT/AFP/Getty Images)
VENICE, ITALY - SEPTEMBER 27: Actor George Clooney sighting at Canal Grande on September 27, 2014 in Venice, Italy. (Photo by Ernesto Ruscio/GC Images)
George Clooney and his fiancee Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world's most romantic settings. (AP Photo/Luigi Costantini)
US actor George Clooney attends a cocktail at the Cipriani hotel on September 27, 2014 in Venice where the actor and his British fiancee, Amal Alamuddin celebrate their wedding. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
US actor Matt Damon (2ndL) attends a cocktail at the Cipriani hotel on September 27, 2014 in Venice where US actor George Clooney and British fiancee, Amal Alamuddin celebrate their wedding. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
VENICE, ITALY - SEPTEMBER 27: Singer of U2 Bono and his wife Ali Hewson sighting at Marco Polo Airport on September 27, 2014 in Venice, Italy. (Photo by Ernesto Ruscio/GC Images)
VENICE, ITALY - SEPTEMBER 27: Singer of U2 Bono and his wife Ali Hewson sighting at Marco Polo Airport on September 27, 2014 in Venice, Italy. (Photo by Ernesto Ruscio/GC Images)
US actor George Clooney arrives at the Aman hotel on September 27, 2014 in Venice where Clooney and British fiancee, Amal Alamuddin celebrate their wedding. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
US actor George Clooney (L) chats with Rande Gerber on September 27, 2014 at the Cipriani Hotel in Venice before his wedding with British Amal Alamuddin in Venice. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
Guests attend a cocktail at the Cipriani hotel on September 27, 2014 in Venice where US actor George Clooney and British fiancee, Amal Alamuddin celebrate their wedding. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
Guests attend a cocktail at the Cipriani hotel on September 27, 2014 in Venice where US actor George Clooney and British fiancee, Amal Alamuddin celebrate their wedding. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
George Clooney, left, and Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world’s most romantic settings. (AP Photo/Luca Bruno)
George Clooney, second right, is flanked by his fiancee Amal Alamuddin, Cindy Crawford, and her husband Rande Gerber, left, as they cruise past St. Mark's Square upon their arrival in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world's most romantic settings. (AP Photo/Luigi Costantini)
George Clooney, right, and Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world’s most romantic settings. (AP Photo/Luca Bruno)
George Clooney, right, and Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world’s most romantic settings. (AP Photo/Luca Bruno)
George Clooney, left, and Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world’s most romantic settings. (AP Photo/Luca Bruno)
George Clooney, right, and Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world’s most romantic settings. (AP Photo/Luca Bruno)
US actor George Clooney (L) and top model Cindy Crawford leave their table on September 27, 2014 at the Cipriani Hotel in Venice before his wedding with British Amal Alamuddin in Venice. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
US actor George Clooney chats with topmodel Cindy Crawford on September 27, 2014 at the Cipriani Hotel in Venice before his wedding with British Amal Alamuddin in Venice. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
US actor George Clooney (L), topmodel Cindy Crawford and her husband Rande Gerber (R) leave their table on September 27, 2014 at the Cipriani Hotel in Venice before his wedding with British Amal Alamuddin in Venice. George Clooney has said goodbye to bachelorhood in Venice with a stag party at his favourite restaurant with Hollywood chums, and was gearing up for a day of glamourous pre-wedding celebrations. The actor had swept into the floating city yesterday with his British fiancee Amal Alamuddin on a watertaxi dubbed 'Amore', zipping up the Grand Canal to cheers from fans at the start of nuptials set to draw out over the weekend. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
George Clooney (L) looks on as he leaves the restaurant Da Ivo with friends and his father during his stag night event in Venice on September 27, 2014. Clooney and his Lebanon-born British fiancee Amal Alamuddin arrived in Venice on September 26 for a spectacular waterfront wedding billed as the party of the year. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read Pierre Teyssot/AFP/Getty Images)
George Clooney (2nd row L) waves to his fans as he leaves the restaurant Da Ivo with friends and his father during his stag night event in Venice on September 27, 2014. Clooney and his Lebanon-born British fiancee Amal Alamuddin arrived in Venice on September 26 for a spectacular waterfront wedding billed as the party of the year. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read Pierre Teyssot/AFP/Getty Images)
George Clooney (2nd row R) waves to his fans waves as he leaves the restaurant Da Ivo with friends and his father during his stag night event in Venice on September 27, 2014. Clooney and his Lebanon-born British fiancee Amal Alamuddin arrived in Venice on September 26 for a spectacular waterfront wedding billed as the party of the year. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read Pierre Teyssot/AFP/Getty Images)
George Clooney looks on as he leaves the restaurant Da Ivo with friends and his father during his stag night event in Venice on September 27, 2014. Clooney and his Lebanon-born British fiancee Amal Alamuddin arrived in Venice on September 26 for a spectacular waterfront wedding billed as the party of the year. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read Pierre Teyssot/AFP/Getty Images)
George Clooney (top C) rides in a boat as he leaves the restaurant Da Ivo with friends and his father during his stag night event in Venice on September 27, 2014. Clooney and his Lebanon-born British fiancee Amal Alamuddin arrived in Venice on September 26 for a spectacular waterfront wedding billed as the party of the year. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read Pierre Teyssot/AFP/Getty Images)
English editor-in-chief of American Vogue Anna Wintour arrives at Marco Polo Airport in Venice on September 26, 2014. The party of the year is happening here: the fresco-adorned Aman hotel on Venice's Grand Canal is feverishly preparing for George Clooney's wedding to Amal Alamuddin, his Lebanon-born British fiancee. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read Pierre Teyssot/AFP/Getty Images)
English editor-in-chief of American Vogue Anna Wintour takes a taxi boat upon her arrival in Venice on September 26, 2014. The party of the year is happening here: the fresco-adorned Aman hotel on Venice's Grand Canal is feverishly preparing for George Clooney's wedding to Amal Alamuddin, his Lebanon-born British fiancee. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read Pierre Teyssot/AFP/Getty Images)
George Clooney (2ndL) and his Lebanon-born British fiancee Amal Alamuddin (2ndR), take a taxi boat upon their arrival in Venice, on September 26, 2014, on the eve of their wedding. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
US actor Richard Kind arrives on September 26, 2014 at Marco Polo Airport in Venice to take a taxi boat for the September 27 wedding of George Clooney and Amal Alamuddin, his Lebanon-born British fiancee. AFP PHOTO / PIERRE TEYSSOT (Photo credit should read Pierre Teyssot/AFP/Getty Images)
US musician Steve Lukather arrives at Marco Polo Airport in Venice on September 26, 2014. The party of the year is happening here: the fresco-adorned Aman hotel on Venice's Grand Canal is feverishly preparing for George Clooney's wedding to Amal Alamuddin, his Lebanon-born British fiancee. AFP PHOTO / ANDREAS SOLARO (Photo credit should read ANDREAS SOLARO/AFP/Getty Images)
George Clooney, right, and Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world’s most romantic settings. (AP Photo/Luca Bruno)
George Clooney, top right, his fiancee Amal Alamuddin, Cindy Crawford, bottom right and her husband Rande Gerber arrive in Venice, Italy, Friday, Sept. 26, 2014. George Clooney and his fiancee Amal Alamuddin arrived in Venice on Friday for their weekend wedding extravaganza, accompanied by loved ones and trailed by a clutch of photographers who recorded their passage along the picturesque Grand Canal. (AP Photo/Luigi Costantini)
George Clooney, right, and his fiancee Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world's most romantic settings. (AP Photo/Luca Bruno)
George Clooney and his fiancee Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world's most romantic settings. (AP Photo/Luigi Costantini)
George Clooney smiles upon his arrival in Venice, Italy, Friday, Sept. 26, 2014. George Clooney and his fiancee Amal Alamuddin arrived in Venice on Friday for their weekend wedding extravaganza, accompanied by loved ones and trailed by a clutch of photographers who recorded their passage along the picturesque Grand Canal. (AP Photo/Luca Bruno)
George Clooney, left, and Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world's most romantic settings. (AP Photo/Luca Bruno)
George Clooney and Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. George Clooney and his fiancee Amal Alamuddin have arrived in Venice for their weekend wedding extravaganza. A clutch of photographers was on hand to record the couple's arrival Friday at the Tronchetto terminal, where they were picked up by Clooney's regular water-taxi driver and taken to the luxury Cipriani hotel. They were accompanied by Cindy Crawford and her husband, among the many celebrities arriving for the festivities. (AP Photo/Luca Bruno)
George Clooney and his fiancee Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world's most romantic settings. (AP Photo/Luigi Costantini)
George Clooney, right, is flanked by his fiancee Amal Alamuddin, Cindy Crawford, bottom right, and her husband Rande Gerber, left, upon their arrival in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world's most romantic settings. (AP Photo/Luigi Costantini)
In this photo taken Sunday, Sept. 7, 2014, George Clooney and his fiancee Amal Alamuddin pose for photographers as they arrive for the "Celebrity Fight Night" foundation gala dinner, in Florence, Italy. George Clooney says he will marry his fiancee in Venice, one of the world's most romantic backdrops. The heartthrob actor revealed that he will marry human rights lawyer Amal Alamuddin in the lagoon city in a couple of weeks. His publicist, Stan Rosenfield, said Monday, Sept. 8, 2014 Clooney revealed the venue but not the exact wedding date during at a star-studded benefit evening in Florence on Sunday.(AP Photo/Francesco Bellini)
In this Sunday, Sept. 7, 2014 file photo George Clooney and his fiancee Amal Alamuddin pose for photographers as they arrive for the "Celebrity Fight Night" foundation gala dinner, in Florence, Italy. George Clooney says he will marry his fiancee in Venice, one of the world's most romantic backdrops. The heartthrob actor revealed that he will marry human rights lawyer Amal Alamuddin in the lagoon city in a couple of weeks. His publicist, Stan Rosenfield, said Monday, Sept. 8, 2014 Clooney revealed the venue but not the exact wedding date during at a star-studded benefit evening in Florence on Sunday. (AP Photo/Francesco Bellini)
George Clooney, right, and his fiancee Amal Alamuddin arrive in Venice, Italy, Friday, Sept. 26, 2014. Clooney, 53, and Alamuddin, 36, are expected to get married this weekend in Venice, one of the world’s most romantic settings. (AP Photo/Luca Bruno)
FLORENCE, ITALY - SEPTEMBER 07: George Clooney (R) and Amal Alamuddin attend the Celebrity Fight Night gala celebrating Celebrity Fight Night In Italy benefitting The Andrea Bocelli Foundation and The Muhammad Ali Parkinson Center on September 7, 2014 in Florence, Italy. (Photo by Rachel Murray/Getty Images for Celebrity Fight Night)
FLORENCE, ITALY - SEPTEMBER 07: George Clooney (R) and fiance Amal Alamuddin attend the Celebrity Fight Night gala celebrating Celebrity Fight Night In Italy benefitting The Andrea Bocelli Foundation and The Muhammad Ali Parkinson Center on September 7, 2014 in Florence, Italy. (Photo by Rachel Murray/Getty Images for Celebrity Fight Night)
FLORENCE, ITALY - SEPTEMBER 07: George Clooney (R) and Amal Alamuddin attend the Celebrity Fight Night gala celebrating Celebrity Fight Night In Italy benefitting The Andrea Bocelli Foundation and The Muhammad Ali Parkinson Center on September 7, 2014 in Florence, Italy. (Photo by Rachel Murray/Getty Images for Celebrity Fight Night)
FLORENCE, ITALY - SEPTEMBER 07: Lior Suchard (R) performs magic for Amal Alamuddin, George Clooney, and Veronica Berti during the Celebrity Fight Night gala celebrating Celebrity Fight Night In Italy benefitting The Andrea Bocelli Foundation and The Muhammad Ali Parkinson Center on September 7, 2014 in Florence, Italy. (Photo by Rachel Murray/Getty Images for Celebrity Fight Night)
FLORENCE, ITALY - SEPTEMBER 07: George Clooney (R) and Amal Alamuddin attend the Celebrity Fight Night gala celebrating Celebrity Fight Night In Italy benefitting The Andrea Bocelli Foundation and The Muhammad Ali Parkinson Center on September , 2014 in Florence, Italy. (Photo by Rachel Murray/Getty Images for Celebrity Fight Night)
FLORENCE, ITALY - SEPTEMBER 07: George Clooney (R) and Amal Alamuddin attend the Celebrity Fight Night gala celebrating Celebrity Fight Night In Italy benefitting The Andrea Bocelli Foundation and The Muhammad Ali Parkinson Center on September 7, 2014 in Florence, Italy. (Photo by Rachel Murray/Getty Images for Celebrity Fight Night)
US actor George Clooney arrives with his fiancee Amal Alamuddin at the Celebrity Fight Night to promote the Andrea Bocelli Foundation on September 7, 2014 in Florence. AFP PHOTO / STR (Photo credit should read -/AFP/Getty Images)
FLORENCE, ITALY - SEPTEMBER 07: Amal Alamuddin and George Clooney attend the Celebrity Fight Night In Italy Benefitting The Andrea Bocelli Foundation and The Muhammad Ali Parkinson Center Gala on September 7, 2014 in Florence, Italy. (Photo by Andrew Goodman/Getty Images for Celebrity Fight Night)
FLORENCE, ITALY - SEPTEMBER 06: George Clooney (R) and fiance Amal Alamuddin attend the Celebrity Fight Night gala celebrating Celebrity Fight Night In Italy benefitting The Andrea Bocelli Foundation and The Muhammad Ali Parkinson Center on September 7, 2014 in Florence, Italy. (Photo by Rachel Murray/Getty Images for Celebrity Fight Night)
LONDON, UNITED KINGDOM - OCTOBER 24: Amal Alamuddin leaving Berners Tavern restaurant on October 24, 2013 in London, England. (Photo by Mark Robert Milan/FilmMagic)
PARIS, FRANCE - FEBRUARY 12: George Clooney attends 'Monuments Men' Paris premiere at Cinema UGC Normandie on February 12, 2014 in Paris, France. (Photo by Julien Hekimian/WireImage)
NEW YORK, NY - MARCH 19: Amal Alamuddin is seen outside her hotel on March 19, 2014 in New York City. (Photo by Raymond Hall/GC Images)
PARIS, FRANCE - FEBRUARY 12: George Clooney attends 'Monuments Men' Paris premiere at Cinema UGC Normandie on February 12, 2014 in Paris, France. (Photo by Julien M. Hekimian/Getty Images)
Lawyer Amal Alamuddin is pictured during a press conference in London on November 5, 2012. The British law firm that employs George Clooney's girlfriend Amal Alamuddin confirmed on Monday April 28, 2014, that the couple were engaged and offered its congratulations. AFP PHOTO/JUSTIN TALLIS (Photo credit should read JUSTIN TALLIS/AFP/Getty Images)
BERLIN, GERMANY - FEBRUARY 08: Actor George Clooney attends 'The Monuments Men' premiere during 64th Berlinale International Film Festival at Berlinale Palast on February 8, 2014 in Berlin, Germany. (Photo by Anita Bugge/WireImage)
FILE - In this Feb. 24, 2013 file photo, actor George Clooney, left, and Stacy Keibler arrive at the Oscars at the Dolby Theatre in Los Angeles. Clooney, 52, Hollywood’s most determined bachelor famous for a litany of fleeting loves, including Keibler, has taken himself off the romantic market and proposed to 36-year-old attorney, Amal Alamuddin. A spokesman for the Oscar-winning actor and producer did not respond to requests for comment Monday, April 28, 2014. (Photo by John Shearer/Invision/AP, file)
FILE - In this Sept. 27, 2010 file photo, American actor George Clooney holds hands with his girlfriend Elisabetta Canalis prior to the presentation of the Armani Spring-Summer 2011 fashion collection, during the fashion week in Milan, Italy. Clooney, 52, Hollywood’s most determined bachelor famous for a litany of fleeting loves, has taken himself off the romantic market and proposed to 36-year-old attorney, Amal Alamuddin. A spokesman for the Oscar-winning actor and producer did not respond to requests for comment Monday, April 28, 2014. (AP Photo/Luca Bruno, file)
FILE - In this Dec. 8, 2004 file photo, cast member George Clooney, left, speaks to the media with British actress Lisa Snowdon as they arrive for the premiere of "Ocean's Twelve," at the Grauman's Chinese Theatre in the Hollywood section, of Los Angeles. Clooney, 52, Hollywood’s most determined bachelor, famous for a litany of fleeting loves, including Snowdon, has taken himself off the romantic market and proposed to 36-year-old attorney Amal Alamuddin. A spokesman for the Oscar-winning actor and producer did not respond to requests for comment Monday, April 28, 2014. (AP Photo/Kevork Djansezian, file)
HOLLYWOOD - DECEMBER 8: Model Lisa Snowdon (L), actor George Clooney and mom Nina Warrer arrive at the Warner Bros. premiere of the film 'Ocean's Twelve' at Grauman's Chinese Theatre December 8, 2004 in Hollywood California. (Photo by Vince Bucci/Getty Images)
LOS ANGELES - JULY 15: Actor George Clooney (L) and Lisa Snowdon arrive at the premiere of Universal's 'The Bourne Supremacy' at the Arclight Cinemas on July 15, 2004 in Los Angeles, California. (Photo by Kevin Winter/Getty Images)
LOS ANGELES - JULY 15: Actor George Clooney (L) and Lisa Snowdon arrive at the premiere of Universal's 'The Bourne Supremacy' at the Arclight Cinemas on July 15, 2004 in Los Angeles, California. (Photo by Kevin Winter/Getty Images)
George Clooney, left, and Sarah Larson arrive at the premiere of "Leatherheads" in Los Angeles on Monday, March 11, 2008. (AP Photo/Matt Sayles)
Cast member/director George Clooney, left, and his girlfriend, Sarah Larson, arrive at the premiere of "Leatherheads" in Los Angeles on Monday, March 11, 2008. (AP Photo/Matt Sayles)
Sarah Larson, girlfriend of actor George Clooney, arrives at the premiere of "Leatherheads" in Los Angeles on Monday, March 11, 2008. (AP Photo/Matt Sayles)
**RETRANSMISSION FOR ALTERNATIVE CROP** George Clooney, nominated for an Oscar for best actor in a leading role for his work in "Michael Clayton," right, and Sarah Larson arrive for the 80th Academy Awards Sunday, Feb. 24, 2008, in Los Angeles. (AP Photo/Chris Carlson)
**ARCHIV** Der Schauspieler George Clooney und Sarah Larson am 11. Maerz 2008 in Los Angeles. George Clooney schien in festen Haenden, weil er Sarah Larson sogar zu offiziellen Auftritten mitnahm. Doch dann bestaetigte er kurz und knapp, dass er wieder solo sei. (AP Photo/Matt Sayles,fls) **FILE**George Clooney, left, and Sarah Larson arrive at the premiere of "Leatherheads" in Los Angeles on Monday, March 11, 2008. (AP Photo/Matt Sayles)
George Clooney, nominated for an Oscar for best actor in a leading role for his work in "Michael Clayton," arrives with his girlfriend Sarah Larson for the 80th Academy Awards Sunday, Feb. 24, 2008, in Los Angeles. (AP Photo/Amy Sancetta)
FILE - In this Sept. 27, 2010 file photo, American actor George Clooney holds hands with his girlfriend Elisabetta Canalis prior to the presentation of the Armani Spring-Summer 2011 fashion collection, during the fashion week in Milan, Italy. Clooney, 52, Hollywood’s most determined bachelor famous for a litany of fleeting loves, has taken himself off the romantic market and proposed to 36-year-old attorney, Amal Alamuddin. A spokesman for the Oscar-winning actor and producer did not respond to requests for comment Monday, April 28, 2014. (AP Photo/Luca Bruno, file)
American actor George Clooney and his girlfriend Elisabetta Canalis pose prior to the presentation of the Armani Spring-Summer 2011 fashion collection, during the fashion week in Milan, Italy, Monday, Sept. 27, 2010. (AP Photo/Luca Bruno)
George Clooney and Elisabetta Canalis arrives at the 82nd Academy Awards Sunday, March 7, 2010, in the Hollywood section of Los Angeles. (AP Photo/Matt Sayles)
George Clooney, left, and Elisabetta Canalis arrive at the 82nd Academy Awards Sunday, March 7, 2010, in the Hollywood section of Los Angeles. (AP Photo/Chris Pizzello)
George Clooney and Elisabetta Canalis are seen backstage after Clooney received the humanitarian award at the 62nd Primetime Emmy Awards Sunday, Aug. 29, 2010, in Los Angeles. (AP Photo/Matt Sayles)
FILE - In this Feb. 24, 2013 file photo, actor George Clooney, left, and Stacy Keibler arrive at the Oscars at the Dolby Theatre in Los Angeles. Clooney, 52, Hollywood’s most determined bachelor famous for a litany of fleeting loves, including Keibler, has taken himself off the romantic market and proposed to 36-year-old attorney, Amal Alamuddin. A spokesman for the Oscar-winning actor and producer did not respond to requests for comment Monday, April 28, 2014. (Photo by John Shearer/Invision/AP, file)
Actors George Clooney, left, and Stacy Keibler arrive at the Oscars at the Dolby Theatre on Sunday Feb. 24, 2013, in Los Angeles. (Photo by John Shearer/Invision/AP)
George Clooney, right, and Stacy Keibler arrive at The Carousel of Hope at The Beverly Hilton Hotel on Saturday, Oct. 20, 2012, in Beverly Hills. (Photo by Jordan Strauss/Invision/AP)
George Clooney, left, and Stacy Keibler arrive at The Carousel of Hope at The Beverly Hilton Hotel on Saturday, Oct. 20, 2012, in Beverly Hills. (Photo by Jordan Strauss/Invision/AP)
George Clooney, left, and Stacy Keibler attend The Carousel of Hope at The Beverly Hilton Hotel on Saturday, Oct. 20, 2012, in Beverly Hills. (Photo by John Shearer/Invision/AP)
George Clooney, a producer of the film "Argo," interacts with girlfriend Stacy Keibler at the premiere of the film at The Academy of Motion Picture Arts & Sciences on Thursday, Oct. 4, 2012, in Beverly Hills, Calif. (Photo by Chris Pizzello/Invision/AP)
George Clooney, left, and Stacy Keibler arrive before the 84th Academy Awards on Sunday, Feb. 26, 2012, in the Hollywood section of Los Angeles. (AP Photo/Amy Sancetta)
Stacy Keibler, left, and George Clooney arrive before the 84th Academy Awards on Sunday, Feb. 26, 2012, in the Hollywood section of Los Angeles. (AP Photo/Joel Ryan)
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Clooney's no stranger to strong women. In fact, for Our Brand Is Crisis, the producer re-worked a role originally meant for a male actor to accommodate his Gravity co-star, Sandra Bullock.

"It was a role written for a man," Clooney explained. "Sandy finally came on board and we sort of switched things around. She was exactly the right guy to make the film."

WATCH: Sandra Bullock Plays Coy About New Boyfriend: 'Everything in My Life Is Great'

Being flexible with gender roles while casting, Clooney explained, is one way for producers to creatively manage the dearth of meaty roles for leading ladies in Hollywood.

"You'll see this happening a lot, where they talk about there aren't a lot of great roles for women," he explained. "The truth of the matter is there are plenty of these films where you can stop and look and just change the gender and make a really interesting film. So we need to start thinking that way."

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