Researchers from Johns Hopkins announced a breakthrough in ALS research, and gave thanks to the Ice Bucket Challenge.
Back when this was all over your Facebook, a lot of people said it wasn't going to do any good.
But $220M later, some Johns Hopkins ALS researchers have a message.
"We've recently made a big breakthrough for ALS..."
In a Reddit AMA, the researchers wrote, "I remember reading a lot of stories about people complaining that the ice bucket challenge was a waste and that scientists weren't using the money to do research, etc. I assure you that this is absolutely false."
"There's this protein called TDP-43 that doesn't seem to be doing its job in the neurons of ALS patients, and for the past decade we've been trying to figure out exactly what it's doing. And now I think we finally figured it out, and the best part is it can be fixed."
The study was published in the journal Science. "Of course, there is always more to be done so please consider donating."
See more on ALS fundraising and the man who started it all, Pete Frates:
Pete Frates and ALS fundraising
ALS researchers to haters: The Ice Bucket Challenge worked
Pete Frates, a former Boston College baseball player stricken with ALS whose Ice Bucket Challenge has raised millions for ALS research, is applauded by Boston Red Sox general manager Ben Cherington, far left, and his wife Julie Frates, middle, along with other family members prior to the home opener baseball game between the Boston Red Sox and the Washington Nationals at Fenway Park in Boston, Monday, April 13, 2015. (AP Photo/Elise Amendola)
NEW YORK, NY - DECEMBER 9: Julie Frates and Pete Frates attend the 2014 Sports Illustrated Sportsman of the Year Award Presentation at Pier 60 on December 9, 2014 in New York City. Credit: Diego Corredor/MediaPunch/IPX
New York Yankees' Derek Jeter, right, speaks former Boston College athlete Pete Frates, diagnosed with ALS disease and inspiration for the Ice Bucket Challenge phenomenon, before a baseball game Sunday, Sept. 28, 2014, at Fenway Park in Boston. This was the last baseball game of Jeter's career. (AP Photo/Steven Senne)
Pete Frates, center, a former Boston College baseball player stricken with ALS whose Ice Bucket Challenge has raised millions for ALS research, is escorted by Boston Red Sox general manager Ben Cherington, second from right, and Pedro Martinez, special assistant to the general manager, right, during ceremonies prior to the home opener baseball game between the Red Sox and the Washington Nationals, in Boston, Monday, April 13, 2015. (AP Photo/Steven Senne)
NEW YORK, NY - DECEMBER 09: Pete Frates and Julie Frates attend the Sportsman Of The Year 2014 Ceremony on December 9, 2014 in New York City. (Photo by Rob Kim/Getty Images for Sports Illustrated)
BOSTON, MA - APRIL 13: New England Patriots quarterback Tom Brady talks with Pete Frates and his wife Julie Frates at Fenway Park on April 13, 2015 in Boston, Massachusetts. (Photo by Maddie Meyer/Getty Images)
BOSTON, MA - APRIL 13: Pete Frates is signed to the Boston Red Sox by Red Sox general manager Ben Cherington at Fenway Park on April 13, 2015 in Boston, Massachusetts. (Photo by Maddie Meyer/Getty Images)
Professor Stephen Hawking during a press conference in London, Tuesday, Dec. 2, 2014. Professor Hawking and Intel discussed the latest developments on how technology enhancements are going to have a wider impact on those, like Professor Hawking that suffer from Amyotrophic lateral sclerosis (ALS). (AP Photo/Kirsty Wigglesworth)
Winners Belgium's Thierry Neuville , second left, co-driver Nicolas Gilsoul , left and second placed Dani Sordo, second right, and co-driver Marc Martin from Spain participating in the ice bucket challenge to support research into amyotrophic lateral sclerosis, or ALS, after the Deutschland Rallye, the German WRC stage , in Trier , Germany, Sunday Aug. 24, 2014. Thierry Neuville held his nerve to win the Rally of Germany after Finland's Jari-Matti Latvala and then Britain's Kris Meeke crashed out of the lead on Sunday. Neuville claimed his first world rally victory ahead of Hyundai teammate Dani Sordo , last year's winner, and third placed Andreas Mikkelsen's Volkswagen Polo R, from Norway. (AP Photo/dpa,Thomas Frey)
Staffers douse Tennessee Gov. Bill Haslam and his wife, Crissy, with cold water on the steps of the state Capitol in Nashville, Tenn., Friday, Aug. 22, 2014. The Haslams were participating in the ice bucket challenge to support research into amyotrophic lateral sclerosis, or ALS, also known as Lou Gehrig's disease. (AP Photo/Erik Schelzig)
Team members pour ice cold water onto Mercedes-AMG's British driver Lewis Hamilton as he takes the 'Ice Bucket Challenge' to raise awareness about ALS (Amyotrophic lateral sclerosis) at the Spa-Francorchamps circuit in Spa on August 22, 2014 ahead of the Belgium Formula One Grand Prix. AFP PHOTO / BELGA PHOTO / NICOLAS LAMBERT ** BELGIUM OUT ** (Photo credit should read NICOLAS LAMBERT/AFP/Getty Images)
Former Thai prime minister Abhisit Vejjajiva braves the 'Ice Bucket Challenge' to raise awareness of amyotrophic lateral sclerosis at the Thai Red Cross Society in Bangkok on August 22, 2014. Numerous people including many celebrities have taken part around the world in recent weeks in the challenge to raise awareness of the disease that targets the nerve cells in the brain and spinal cord. AFP PHOTO / PORNCHAI KITTIWONGSAKUL (Photo credit should read PORNCHAI KITTIWONGSAKUL/AFP/Getty Images)
NEW YORK - JULY 04: Michael Goldsmith, a sufferer of Amyotrophic Lateral Sclerosis (ALS), often referred to as 'Lou Gehrig's Disease' watches an onscreen presentation with son, Austin, prior to the game between the New York Yankees and the Toronto Blue Jays on July 4, 2009 at Yankee Stadium in the Bronx borough of New York City. (Photo by Nick Laham/Getty Images)
COLOGNE, GERMANY - DECEMBER 07: Barbara Schoeneberger and TV host Guenther Jauch take part in the 'Ice Bucket Challenge' during the 2014! Menschen, Bilder, Emotionen - RTL Jahresrueckblick show on December 7, 2014 in Cologne, Germany. (Photo by Andreas Rentz/Getty Images)
Heidi Klum, left, and Tim Gunn, right, take part in the ALS Ice Bucket Challenge during the Project Runway finale at Mercedes-Benz Fashion Week on Friday, Sept. 5, 2014 in New York. (Photo by Andy Kropa/Invision/AP)
Former Tennessee Titans linebacker Tim Shaw is dunked with water as he takes the ALS ice bucket challenge in the second quarter of a preseason NFL football game between the Titans and the Minnesota Vikings Thursday, Aug. 28, 2014, in Nashville, Tenn. Shaw has announced that he has ALS. (AP Photo/Mark Zaleski)
Seth Meyers backstage at the 66th Primetime Emmy Awards at the Nokia Theatre L.A. Live on Monday, Aug. 25, 2014, in Los Angeles. (Photo by Matt Sayles/Invision for the Television Academy/AP Images)
U.S. Rep. Vance McAllister is doused as he takes the ice bucket challenge after qualifying for his re-election bid Friday, Aug. 22, 2014, in Baton Rouge, La. The Republican congressman has drawn a crowded field of challengers after a cheating scandal earlier this year. (AP Photo/Melinda Deslatte)
FILE - This Aug. 20, 2014 file photo shows Tennessee Titans players taking part in the ALS Ice Bucket Challenge after NFL football practice in Nashville, Tenn. Former Titans linebacker Tim Shaw has announced that he has ALS and visited the facility and witnessed the event to raise money and awareness to battle the disease. The phenomenal success of the fundraising craze is making charitable organizations rethink how they connect with a younger generation of potential donors, specifically through social media. (AP Photo/Mark Humphrey, File)
Major League Baseball Commissioner-elect Rob Manfred participates in the ALS Ice-Bucket Challenge outside the organization's headquarters in New York, Wednesday, Aug. 20, 2014. Manfred participated with more than 160 other MLB employees to raise more than $16,000 for the ALS Association. (AP Photo/Vanessa A. Alvarez)
Beryl Lipton, left, douses Matt Lee during the ice bucket challenge at Boston's Copley Square, Thursday, Aug. 7, 2014 to raise funds and awareness for ALS. The idea is: pay up for charity or get doused. The fund-raising phenomenon is catching on fast, propelled by popular videos of the dunkers and the dunked _ including famous athletes and entertainers _ posted on social media sites. And the challenges are raising tens of thousands of dollars and immeasurable awareness for causes from ALS to breast cancer to a camp for kids whoâve lost a father to war. (AP Photo/Elise Amendola)
WASHINGTON, DC - AUGUST 22: Manager Bruce Bochy #15 of the San Francisco Giants takes the ALS Ice Bucket Challenge after the game against the Washington Nationals at Nationals Park on August 22, 2014 in Washington, DC. (Photo by Greg Fiume/Getty Images)