Rob Lowe talks 'terrifying' experience with cancer and his return to television

Before you go, we thought you'd like these...
Before you go close icon
Rob Lowe on 'The Grinder' and Stand Up 2 Cancer

By MARAH ALINDOGAN

Rob Lowe doesn't just stand up to cancer, he supports their cause.

"I lost my great-grandmother, grandmother and mother all to breast cancer," Lowe told AOL in an exclusive interview.

In 2002, the 51-year-old actor became the first ever spokesman for breast cancer awareness.

"[Cancer] is terrifying," Lowe admitted while announcing his new fundraising campaign with MasterCard and Stand Up To Cancer. "It's definitely not something you would wish on somebody."

More images of Rob Lowe:
29 PHOTOS
Rob Lowe
See Gallery
Rob Lowe talks 'terrifying' experience with cancer and his return to television
SAN DIEGO, CA - JULY 09: Actor Rob Lowe attends SiriusXM's Entertainment Weekly Radio Channel Broadcasts From Comic-Con 2015 at Hard Rock Hotel San Diego on July 9, 2015 in San Diego, California. (Photo by Vivien Killilea/Getty Images for SiriusXM)
Actor Rob Lowe, left, jokingly distracts a Memphis Grizzlies player at the free throw line during the second half of an NBA basketball game against the Los Angeles Clippers, Monday, Feb. 23, 2015, in Los Angeles. The Grizzlies won 90-87. (AP Photo/Jae C. Hong)
LOS ANGELES, CA - FEBRUARY 22: Actor Rob Lowe (L) and Sheryl Berkoff attend the 23rd Annual Elton John AIDS Foundation Academy Awards Viewing Party on February 22, 2015 in Los Angeles, California. (Photo by Dimitrios Kambouris/Getty Images for EJAF)
LOS ANGELES, CA - OCTOBER 20: Actor Rob Lowe and singer Johnny Mathis attend the Barlow Respiratory Hospital;s 4th Annual Bernie Brillstein Golf Classic Awards Dinner at the Wilshire Country Club on October 20, 2014 in Los Angeles, California. (Photo by Alberto E. Rodriguez/Getty Images)
LOS ANGELES, CA - OCTOBER 20: Actor Rob Lowe and talent agent Richard Weitz attend the Barlow Respiratory Hospital;s 4th Annual Bernie Brillstein Golf Classic Awards Dinner at the Wilshire Country Club on October 20, 2014 in Los Angeles, California. (Photo by Alberto E. Rodriguez/Getty Images)
BARCELONA, SPAIN - JUNE 19: Jason Segel, Cameron Diaz and Rob Lowe pose for a photocall for their latest film 'Sex Tape' at the Hotel Mandarin on June 19, 2014 in Barcelona, Spain. (Photo by Robert Marquardt/Getty Images)
BARCELONA, SPAIN - JUNE 18: (L-R) Jason Segel, Cameron Diaz and Rob Lowe pose during a photocall for their latest film 'Sex Tape' on June 18, 2014 in Barcelona, Spain. (Photo by Miquel Benitez/Getty Images)
NEW YORK, UNITED STATES - APRIL 9: American actor Rob Lowe promotes his new book 'Love Life' at Barnes & Noble bookseller at 5th Avenue, on April 9, 2014 in New York, United States. (Photo by Cem Ozdel/Anadolu Agency/Getty Images)
BARCELONA, SPAIN - JUNE 17: Rob Lowe (L) and his son John Owen Lowe (C) are seen on June 17, 2014 in Barcelona, Spain. (Photo by Europa Press/Europa Press via Getty Images)
NEW YORK, NY - APRIL 09: Rob Lowe visits Fox News' 'The O'Reilly Factor' at Fox News Studios on April 9, 2014 in New York City. (Photo by Rob Kim/Getty Images)
NEW YORK, NY - APRIL 08: Actor Rob Lowe is seen on April 8, 2014 in New York City. (Photo by DVT/Star Max/GC Images)
GOOD MORNING AMERICA - Rob Lowe is a guest on 'Good Morning America,' 4/8/14, airing on the ABC Television Network. (Photo by Fred Lee/ABC via Getty Images)
NEW YORK, NY - APRIL 08: Actor Rob Lowe (C) with Sirius XM's The MOMS with Denise Albert and Melissa Musen Gerstein attend Rob Lowe's 'Love Life' book launch hosted by The Mom at Paramount Hotel on April 8, 2014 in New York City. (Photo by Robin Marchant/Getty Images)
SANTA MONICA, CA - MARCH 16: (L-R) Mary Nilan, President of NBC Television Jennifer Nicholson Salke, Founder, President and CEO of The Get In Touch Foundation Mary Ann Wasil, actor Rob Lowe, author Angelique L'Amour, Dr. Nalini Chilkov and Dr. Kristi Funk attend the Get In Touch Foundation's 2014 Pretty In Pink Luncheon and Women of Strength Awards at the Casa del Mar Hotel on March 16, 2014 in Santa Monica, California. (Photo by Jesse Grant/Getty Images for The Get In Touch Foundation)
THE TONIGHT SHOW WITH JAY LENO -- Episode 142 -- Pictured: (l-r) Actor Rob Lowe during an interview with host Jay Leno on January 5, 1993 -- (Photo by: Gary Null/NBC/NBCU Photo Bank via Getty Images)
SANTA MONICA, CA - MARCH 16: Actor Rob Lowe attends the Get In Touch Foundation's 2014 Pretty In Pink Luncheon and Women of Strength Awards at the Casa del Mar Hotel on March 16, 2014 in Santa Monica, California. (Photo by Jesse Grant/Getty Images for The Get In Touch Foundation)
LOS ANGELES, CA - JANUARY 12: Actors Rob Lowe and Josh Radnor attend HBO's Post 2014 Golden Globe Awards Party at Circa 55 Restaurant on January 12, 2014 in Los Angeles, California. (Photo by Mike Windle/Getty Images)
BEVERLY HILLS, CA - JANUARY 12: 71st ANNUAL GOLDEN GLOBE AWARDS -- Pictured: (l-r) Actor Michael Douglas, actor Rob Lowe and guest arrive to the 71st Annual Golden Globe Awards held at the Beverly Hilton Hotel on January 12, 2014 -- (Photo by Christopher Polk/NBC/NBC via Getty Images)
PARKS AND RECREATION -- 'Ann & Chris' Episode 613 -- Pictured: (l-r) Rob Lowe as Chris Traeger, Rashida Jones as Ann Perkins -- (Photo by: Ben Cohen/NBC/NBCU Photo Bank via Getty Images)
PARKS AND RECREATION -- 'Ann & Chris' Episode 613 -- Pictured: (l-r) Nick Offerman as Ron Swanson, Rob Lowe as Chris Traeger -- (Photo by: Colleen Hayes/NBC/NBCU Photo Bank via Getty Images)
PARKS AND RECREATION -- 'Ann & Chris' Episode 613 -- Pictured: Rob Lowe as Chris Traeger -- (Photo by: Colleen Hayes/NBC/NBCU Photo Bank via Getty Images)
BEVERLY HILLS, CA - NOVEMBER 04: Actor Rob Lowe (L) and Sheryl Berkoff arrive at National Geographic Channel presents Los Angeles premiere of 'Killing Kennedy' at Saban Theatre on November 4, 2013 in Beverly Hills, California. (Photo by Rodrigo Vaz/FilmMagic)
GOOD MORNING AMERICA - Rob Lowe visits GOOD MORNING AMERICA', 10/30/13, airing on the ABC Television Network. (Photo by Ida Mae Astute/ABC via Getty Images) ROB LOWE
WASHINGTON, DC - OCTOBER 28: Rob Lowe and Sheryl Berkoff attend the National Geographic Channel's 'Killing Kennedy' World Premiere at The Newseum on October 28, 2013 in Washington, DC. (Photo by Kris Connor/Getty Images)
STUDIO CITY, CA - OCTOBER 16: Rob Lowe attends the 'Parks And Recreation' 100th episode celebration held at CBS Studios - Radford on October 16, 2013 in Studio City, California. (Photo by Michael Tran/FilmMagic)
STUDIO CITY, CA - OCTOBER 16: (L-R) Rashida Jones, Nick Offerman, Retta, Michael Schur, Adam Scott, Amy Poehler, Chris Pratt, Aziz Ansari, Jim O'Heir, Aubrey Plaza and Rob Lowe attend the 'Parks And Recreation' 100th episode celebration held at CBS Studios - Radford on October 16, 2013 in Studio City, California. (Photo by Michael Tran/FilmMagic)
STUDIO CITY, CA - OCTOBER 16: (L-R) Amy Poehler, Rob Lowe and Rashida Jones attend the 'Parks And Recreation' 100th episode celebration held at CBS Studios - Radford on October 16, 2013 in Studio City, California. (Photo by Michael Tran/FilmMagic)
BEVERLY HILLS, CA - FEBRUARY 22: (EXCLUSIVE ACCESS, SPECIAL RATES APPLY) Rob Lowe and Eddie Murphy attend the 2015 Vanity Fair Oscar Party hosted by Graydon Carter at the Wallis Annenberg Center for the Performing Arts on February 22, 2015 in Beverly Hills, California. (Photo by Kevin Mazur/VF15/WireImage)
of
SEE ALL
BACK TO SLIDE
SHOW CAPTION +
HIDE CAPTION


Rather than donating a few dollars here and there, the star has a more hands-on approach when it comes to making an impact. He's spent much of his time speaking to those directly affected by cancer across the county.

"It's a great bonding experience because we all live different lives from one another."

The funny man also revealed that from these experiences, he's not shy about sharing them with anyone willing to listen.

"Support from family and friends is critical," Lowe explained. "Studies show that people with support do much, much better than those who don't have it."

Though the star has devoted much of his time working tirelessly as a crusader for cancer, he also dished on a highly-anticipated project in the works.

The Emmy Award nominee took a hiatus from television after winning over America's hearts as city manager Chris Traeger in "Parks and Recreation," but he'll be back to his ridiculous on-screen antics on Fox's "The Grinder" this fall.

However, the decision to get back into television was not as easy as you might think.

"I was looking long and hard for something that could be a worthy successor to 'The West Wing' and 'Parks & Recreation," he revealed.

His co-star Fred Savage, who plays his straitlaced brother, might have made that choice a tad bit easier.

"I've always been a Fred fan – 'Wonder Years' is one of my favorite shows of all time and 'Princess Bride' is one of my favorite movies of all time," Lowe dished.

Could there be a possible bromance in the air? Lowe certainly has us speculating.

"We just have a really special chemistry together. I don't know why because I've never met him before this show." Lowe gushed. "The two of us together, we just have a blast."

While we can only imagine the antics these two cause together, we certainly expect to see some of that chemistry on screen.

"I aim to make you laugh – that's my new mission in life," said Lowe.
Read Full Story

From Our Partners