Ellen Pompeo speaks out on Patrick Dempsey's 'Grey's Anatomy' exit

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Ellen Pompeo Speaks Out on McDreamy's Death

The tragic end of Mer-Der shook us all to our core.

Now, after having a weekend to digest what it all means, Ellen Pompeo (who plays Dr. Meredith Grey) is speaking out about the loss of her on-screen husband, Derek Shepherd.

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"I have always said what keeps me going is the fans. Knowing we move you and inspire you. There are so many people out there who have suffered tremendous loss and tragedy," she wrote in a tweet on Monday.

"Husbands and wives of soldiers, victims of senseless violence and parents who have lost children," she continued. "People who get up each day and do what feels like is the impossible. So it is for these people and in the spirit of resilience I am honored and excited to tell the story of how Meredith goes on in the face of what feels like the impossible. I hope you will all join me on her journey."

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The death of McDreamy ended Patrick Dempsey's 11 season run -- nearly 250 episodes! -- on the Shonda Rhimes medical drama and the actor offered fans this little farewell.

"I want to thank all the fans, what an incredible 11 yrs, I love you all," Dempsey tweeted out Friday after the episode aired.

The 49-year-old actor offered a bit more of an explanation to Entertainment Weekly about the decision behind Derek's death, though still not much. "It just sort of evolved," he said. "It just kind of happened. [Being written off] was something that was kind of surprising and uh, just naturally came to be. I like the way it has all played out."

Dempsey was on hiatus for six episodes of the season -- during which he spent a majority of his time traveling and racing -- and reveals that there wasn't much discussion when it came to his character's death. He found out it was happening earlier this year in February or March and filmed his final scenes to little fanfare.

NEWS: Ellen Pompeo Plans to Quit Acting After Grey's

"It was very quiet, very quiet. I very quietly left," he said. "It was beautiful. It was raining, which was really touching. I got in my Panamera, got in rush hour traffic, and two hours later I was home. I'm emotional now talking about it because you start to look at the reality of it."

Thinking about his costar Pompeo and their chemistry also caused our McDreamy to get emotional.

"It's magic. It's beautiful," he said after hesitating and tearing up. "We're like a married couple. It's beem 10 years, and it was magic from the beginning. [Great] chemistry right away."

NEWS: How Ellen Pompeo Kept Her Surprise Baby a Secret for 2 Months!

Following her leading man's death, Rhimes issued this statement:

"Derek Shepherd is and will always be an incredibly important character – for Meredith, for me and for the fans. I absolutely never imagined saying goodbye to our 'McDreamy.' Patrick Dempsey's performance shaped Derek in a way that I know we both hope became a meaningful example – happy, sad, romantic, painful and always true – of what young women should demand from modern love. His loss will be felt by all."

The rest of Grey Sloan Memorial Hospital gang will grapple with Derek's in special two-hour episode this Thursday on ABC at 8pm. For now, relive Mer-Der's best, most romantic moments!

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Ellen Pompeo speaks out on Patrick Dempsey's 'Grey's Anatomy' exit
UNITED STATES - OCTOBER 19: GREY'S ANATOMY - 'Staring at the Sun' - The O'Malley Family visits George at the hospital, Meredith is determined to have a more positive outlook on life, Derek and Addison strive for a civil relationship, and Richard endeavors to reunite with his wife, Adele, on 'Grey's Anatomy,' THURSDAY, NOVEMBER 16 (9:00-10:01 p.m., ET) on the ABC Television Network. (Photo by Karen Neal/ABC via Getty Images)
UNITED STATES - AUGUST 14: GREY'S ANATOMY - 'Time Has Come Today' - The doctors of Seattle Grace help Izzie cope with the loss of her fiancé, Denny, and her decision to quit the internship program. Meredith must decide what the future holds after her hospital liaison with Derek. The Chief is confronted by his wife, Adele, after spending the night in his office, and George seeks relationship advice from a surprising source, on the season premiere of 'Grey's Anatomy,' THURSDAY, SEPTEMBER 21 (9:00-10:01 p.m., ET) on the ABC Television Network. (Photo by Ron Tom/ABC via Getty Images)
GREY'S ANATOMY - 'I Want You With Me' - 'Grey's Anatomy' returns for its monumental tenth season with a two-hour event, THURSDAY, SEPTEMBER 26 (9:00-11:00 p.m., ET) on the ABC Television Network. In the second hour, 'I Want You With Me' (10:00-11:00 p.m.), the fight continues to save those affected by the storm, Callie makes a bold decision regarding her relationship, and the doctors come together upon receiving devastating news. (Photo by Danny Feld/ABC via Getty Images) PATRICK DEMPSEY, ELLEN POMPEO
UNITED STATES - AUGUST 08: GREY'S ANATOMY- 'Here Comes the Flood' - A plumbing leak becomes a deluge and wreaks havoc at Seattle Grace, as the Chief attempts to implement new teaching policies and George tries to retake his residency exam; meanwhile Derek hopes to move the roommates out of Meredith's house, to their surprise, on 'Grey's Anatomy,' THURSDAY, OCTOBER 9 (9:00-10:01 p.m., ET) on the ABC Television Network. (Photo by Eric McCandless/ABC via Getty Images)
UNITED STATES - APRIL 17: GREY'S ANATOMY - 'The Becoming' - The nurses' objections to McSteamy's trysts lead to the instating of a new 'date and tell' policy. Meanwhile news of Burke's latest career achievements force Cristina to face her feelings for her ex, Meredith and Derek admit a veteran soldier into their clinical trial, and Callie turns to Sloan in her time of need, on 'Grey's Anatomy,' THURSDAY, MAY 8 (9:00-10:02 p.m., ET) on the ABC Television Network. (Photo by Vivian Zink/ABC via Getty Images)
GREY'S ANATOMY - 'Can't Fight Biology' - Things are hostile on all fronts when a visit to the obstetrician results in some disturbing news for Meredith and Derek, and Lexie loses it when she notices Meredith and April getting closer. Meanwhile a car crash brings in multiple traumas and Jackson tries using his physical attributes to get ahead in the operating room, while Cristina's self-doubt carries outside of the hospital and into her house hunting with Owen, on 'Grey's Anatomy,' THURSDAY, OCTOBER 14 (9:00-10:01 p.m., ET) on the ABC Television Network. (Photo by Adam Taylor/ABC via Getty Images) PATRICK DEMPSEY, ELLEN POMPEO
UNITED STATES - AUGUST 28: GREY'S ANATOMY - 'There's No 'I' in Team' - Bailey heads up a team of surgeons performing a 'domino procedure' in which each surgery hinges on the one preceding it; Derek gets sole credit for the brain tumor study he did with Meredith; Lexie goes to great lengths to have George notice her romantically, and Sloan counsels a desperate Callie on the ways of love, on 'Grey's Anatomy,' THURSDAY, OCTOBER 23 (9:00-10:01 p.m., ET) on the ABC Television Network. (Photo by Eric McCandless/ABC via Getty Images)
GREY'S ANATOMY - 'Shock to the System' -- After weeks of concealing the fact she was pregnant and miscarried, Meredith at last tells Derek and is finally cleared to return to her surgical duties in the wake of the hospital shooting spree; Cristina experiences post-traumatic stress disorder in the midst of an operation; and Bailey refuses to let Alex operate until he agrees to have the bullet in his chest removed, on 'Grey's Anatomy,' THURSDAY, SEPTEMBER 30 (9:00-10:01 p.m., ET) on the ABC Television Network. (Photo by Eric McCandless/ABC via Getty Images) PATRICK DEMPSEY, ELLEN POMPEO
UNITED STATES - AUGUST 08: GREY'S ANATOMY- 'Here Comes the Flood' - A plumbing leak becomes a deluge and wreaks havoc at Seattle Grace, as the Chief attempts to implement new teaching policies and George tries to retake his residency exam; meanwhile Derek hopes to move the roommates out of Meredith's house, to their surprise, on 'Grey's Anatomy,' THURSDAY, OCTOBER 9 (9:00-10:01 p.m., ET) on the ABC Television Network. (Photo by Eric McCandless/ABC via Getty Images)
UNITED STATES - APRIL 15: GREY'S ANATOMY - 'What a Difference a Day Makes' - As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER. Meanwhile, Izzie fears the worst when she begins experiencing familiar symptoms, on 'Grey's Anatomy,' THURSDAY, MAY 7 (9:00-10:02 p.m., ET) on the ABC Television Network. (Photo by Scott Garfield/ABC via Getty Images)
GREY'S ANATOMY - 'Superfreak' - When Derek receives an unexpected and unwelcome visit from his estranged sister, Amelia, issues between the siblings -- both past and present -- come to the surface; the Chief tries to help Alex when he notices that he's refusing to use the elevators after his near-fatal shooting; and Meredith and Derek continue their efforts to ease Cristina back into surgery after her post-traumatic stress, on 'Grey's Anatomy,' THURSDAY, OCTOBER 7 (9:00-10:01 p.m., ET) on the ABC Television Network. (Photo by Richard Cartwright/ABC via Getty Images) PATRICK DEMPSEY, ELLEN POMPEO, CATERINA SCORSONE
UNITED STATES - AUGUST 14: GREY'S ANATOMY - 'Time Has Come Today' - The doctors of Seattle Grace help Izzie cope with the loss of her fiancé, Denny, and her decision to quit the internship program. Meredith must decide what the future holds after her hospital liaison with Derek. The Chief is confronted by his wife, Adele, after spending the night in his office, and George seeks relationship advice from a surprising source, on the season premiere of 'Grey's Anatomy,' THURSDAY, SEPTEMBER 21 (9:00-10:01 p.m., ET) on the ABC Television Network. (Photo by Ron Tom/ABC via Getty Images)
GREY'S ANATOMY - ABC's 'Grey's Anatomy' stars Ellen Pompeo as Dr. Meredith Grey and Patrick Dempsey as Dr. Derek Shepherd. (Bob D'Amico/ABC via Getty Images)
UNITED STATES - AUGUST 28: GREY'S ANATOMY - 'There's No 'I' in Team' - Bailey heads up a team of surgeons performing a 'domino procedure' in which each surgery hinges on the one preceding it; Derek gets sole credit for the brain tumor study he did with Meredith; Lexie goes to great lengths to have George notice her romantically, and Sloan counsels a desperate Callie on the ways of love, on 'Grey's Anatomy,' THURSDAY, OCTOBER 23 (9:00-10:01 p.m., ET) on the ABC Television Network. (Photo by Eric McCandless/ABC via Getty Images)
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