UK House of Commons OKs making babies from DNA of 3 people

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LONDON (AP) -- British lawmakers in the House of Commons voted Tuesday to allow scientists to create babies from the DNA of three people - a move that could prevent some children from inheriting potentially fatal diseases from their mothers.

The vote in the House of Commons was 382-128 in favor. The bill must next be approved by the House of Lords before becoming law. If so, it would make Britain the first country in the world to allow embryos to be genetically modified.

The controversial techniques - which aim to prevent mothers from passing on inherited diseases - involve altering a human egg or embryo before transferring it into the mother. British law currently forbids any such modification and critics say approving the techniques could lead to the creation of "designer babies."

Defects in the mitochondria can result in diseases including muscular dystrophy, heart, kidney and liver failure and severe muscle weakness.

The technology is completely different from that used to create genetically modified foods, where scientists typically select individual genes to be transferred from one organism into another.

In the House of Commons, health minister Jane Ellison kicked off the debate by urging support for the change.

"This is a bold step to take, but it is a considered and informed step," she said, of the proposed technology to help women with mitochondrial diseases.

Critics, however, say the techniques cross a fundamental scientific boundary, since the changes made to the embryos will be passed on to future generations.

"(This is) about protecting children from the severe health risks of these unnecessary techniques and protecting everyone from the eugenic designer-baby future that will follow from this," said David King, director of the secular watchdog group Human Genetics Alert.

The techniques would likely only be used in about a dozen British women every year who have faulty mitochondria, the energy-producing structures outside a cell's nucleus. To fix that, scientists remove the nucleus DNA from the egg of a prospective mother and insert it into a donor egg from which the nucleus DNA has been removed. This can be done either before or after fertilization.

The resulting embryo would end up with the nucleus DNA from its parents but the mitochondrial DNA from the donor. Scientists say the DNA from the donor egg amounts to less than 1 percent of the resulting embryo's genes.

Last year, the U.S. Food and Drug Administration held a meeting to discuss the techniques and scientists warned it could take decades to determine if they are safe. Experts say the techniques are likely being used elsewhere, such as in China and Japan, but are mostly unregulated.

Rachel Kean, whose aunt suffered from mitochondrial disease and had several miscarriages and stillbirths, said she hoped British politicians would approve the techniques. Kean, an activist for the Muscular Dystrophy Campaign, said her mother is also a carrier of mitochondrial disease and that she herself would like the option one day of having children who won't be affected.

"Knowing that you could bring a child into this world for a short, painful life of suffering is not something I would want to do," she said.

A spokesman for Prime Minister David Cameron said he was a "strong supporter" of the change. Cameron had a severely disabled son, Ivan, who died at age 6 in 2009, from a rare form of epilepsy.

Lisa Jardine, who chaired a review into the techniques conducted by Britain's fertility regulator, said each case will be under close scrutiny and that doctors will track children born using this technique as well as their future offspring. She acknowledged there was still uncertainty about the safety of the novel techniques.

"Every medical procedure ultimately carries a small risk," she said, pointing out that the first baby created using in-vitro fertilization would never have been born if scientists hadn't risked experimenting with unproven methods.

Yet Kean said she understood the opposition to the new technology.

"It's everybody's prerogative to object, due to their own personal beliefs," she said. "But to me the most ethical option is stopping these devastating diseases from causing suffering in the future."

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