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Genetic mapping triggers new hope on Schizophrenia

Human Brain Injury


WASHINGTON (AP) -- Scientists have linked more than 100 spots in our DNA to the risk of developing schizophrenia, casting light on the mystery of what makes the disease tick.

Such work could eventually point to new treatments, although they are many years away. Already, the new results provide the first hard genetic evidence to bolster a theory connecting the immune system to the disease.

More than 100 researchers from around the world collaborated in the biggest-ever genomic mapping of schizophrenia, for which scientists had previously uncovered only about a couple of dozen risk-related genes.

The study included the genetic codes of more than 150,000 people - nearly 37,000 of them diagnosed with the disease. Researchers found 108 genetic markers for risk of getting the disease, 83 of them not previously reported. And scientists say there are still likely more to be found.

"It's a genetic revelation; schizophrenia has been a mystery," said study co-author Steve McCarroll, director of genetics for the Broad Institute of MIT and Harvard. "Results like this give you things to work on. It takes it out of the zone of guesses about which genes are relevant."

The results were released Monday by the journal Nature. It takes large studies to ferret out genes related to schizophrenia risk because each gene generally has only a very weak effect.

Schizophrenia is a debilitating mental disorder that makes it hard to tell the difference between what is real and not real, and affects about one out of every 100 people. Studies estimate that it costs $60 billion in the U.S. each year. Scientists have long known that genes play a part, and this work further confirms that.

The results are a "big step" toward finding drug therapies, said study lead author Dr. Michael O'Donovan, deputy director of the MRC Centre for Neuropsychiatric Genetics and Genomics at Cardiff University School of Medicine in Wales. While 108 genetic markers are a lot, the study authors say they tend to implicate a narrower group of biological functions, giving some but not too many hints for scientists to pursue.

"It's a map or maze. It's telling you were to start, it's not telling you where to end," O'Donovan said.

Scientists who didn't work on the study were excited by the possibilities it opens up.

"This makes me more optimistic than I was yesterday," said American Psychiatric Association president Dr. Paul Summergrad, psychiatrist-in-chief at Tufts Medical Center.

Dr. Thomas Insel, director of the National Institute of Mental Health, which funded the work, said the study provides useful hints about the biology of the disease, especially the link to the immune system.

"This really is a big step forward," Insel said. "It's not an answer; it's a step forward toward an answer."

Scientists already knew that families with autoimmune disorders tend to have higher rates of schizophrenia, and there's been a link between certain viral infections in the second trimester of pregnancy and higher rates of schizophrenia in offspring, Insel said.

With the new work, "now it's very clear that there's something going in the immune system" with schizophrenia, said Eric Lander, founding director of the Broad Institute, which was heavily involved in the research.

O'Donovan figures most people have at least 20 to 30 genes that nudge them toward developing schizophrenia, probably many more, but don't have the disorder itself. That's because it may still take an environmental or emotional trigger to bring on the illness.

Insel was especially excited about one study finding, that people with the most genetic markers were 15 times more likely to have schizophrenia than those with the fewest markers. He said he hoped that scientists can eventually develop a genetic test to identify young people at high risk for the disease, so they can be offered early treatment.

But O'Donovan and McCarroll said the work is way too preliminary to even hint at that. Even the people with elevated risk of schizophrenia according to the test were far more likely to be free of the disorder than to have it.

As for developing treatments, "I don't want to pretend than anybody's going to make drugs easily," Lander said.

But he said the study of schizophrenia genetics is now to the point that "we can actually turn the lights on and see what's going on."

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Innocent July 22 2014 at 9:17 AM

Thank God! There are so many people who have been diagnosed or just say they are Bipolar, but are actually Schizophrenic. Both mental disorders use the same medicines and have similar issues. The medicines have side effects that make it hard to function, for some Schizophrenics, so they refuse to take them. I hope the new drugs created from this research will not have these energy zapping side effects! I am excited!

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1 reply
Franco Innocent July 22 2014 at 9:57 PM

How exited? :O)

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stengernc July 22 2014 at 7:35 AM

Maybe there is hope for the TEA PARTY after all.

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4 replies
Christopher July 22 2014 at 5:06 AM

its truely amazing that they found these genes that look like gears in a watch or clock of some sort. Either way I think this is all something made up to try to get us to read this article

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4 replies
am0714 July 22 2014 at 9:57 AM

Cure this decease and change the world !

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2 replies
savannahswithgod am0714 July 22 2014 at 10:45 AM

You mean break the banks across the World. They got no reason to cure nothing!

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1 reply
Raven's Nest savannahswithgod July 22 2014 at 8:10 PM

Down right callous!

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Franco am0714 July 22 2014 at 10:00 PM

Let's start with the preliminary cold first! :/

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stock market July 22 2014 at 9:41 AM

We have a neighbor, sweet lady, but when something gets into her mind, you can't change it. At times she thinks her one neighbor is spying on her, then she believes a little child is playing a flute just to annoy her. It isn't a flute she hears...it is a morning dove early in the a.m. She has spent thousands to darken her rooms and remodeling one room just not to hear that beautiful dove in the a.m. There is nothing we can say that will change her mind so I doubt she would ever take a pill willingly. It is very sad to watch.

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mbfva July 22 2014 at 11:58 AM

Monies are better spent on human (DNA) life research as opposed to searching for life in outer space. WTG National Institute of Mental Health! Way to fund your own study, way to find 83 previously unknown markers, way to further link this disease to auto immune difficiencies & viral infections in certain trimesters. You're all doing a wonderful job. Keep up the impressive work!

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1 reply
tma2c mbfva July 22 2014 at 7:59 PM

more abortion clinics

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john chism July 22 2014 at 2:48 PM

There may be a Cure to Liberalism in the future. Where do I donate to this to get it done? Yesterday is too late.

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2 replies
blackcoffeeparty john chism July 22 2014 at 4:16 PM

Was thinking the same thing about Conservatism. But guess there is no way to resurrect a dead brain

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JOSEPH john chism July 22 2014 at 6:06 PM

it sounds like your thinking process is off, you might need meds. thats quite a leap from this tragic disease to "liberalism".
if you have extra money to donate, make a contribution to mental health agencies like the VA, they can use it. if not, see a psychiatrist. I mean it.

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Jeremiah July 22 2014 at 4:37 PM

Genetic mapping shows left thinking liberals are far more likely to be politically contaminated than right thinking protectors.

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shevon July 22 2014 at 6:36 PM

Great!! I sure hope at some point in time they can find a cure or at least medication that actually works. It is awful when you have known somebody in the "normal state of mind" and then encounter them in the "delusional state of mind". I have a friend who suffers from this and it breaks my heart. Though this research is still in the preliminary stage, I hope more funds are put towards this research. I am sure between schizophrenia and bi-polar, better medication will reduce the number of people in jail and save families and tax payers.

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Raven's Nest July 22 2014 at 7:59 PM

Real hope for a horrifically debilitating disease. As a retired behavioral health professional, I find this a true blessing!

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