Why Pharmacyclics Inc. Shares Soared

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Although we don't believe in timing the market or panicking over market movements, we do like to keep an eye on big changes -- just in case they're material to our investing thesis.

What: Shares of Pharmacyclics , a clinical-stage biopharmaceutical company focused on developing small-molecule drugs for the treatment of cancer and immune system diseases, jumped as much as 11% after Deutsche Bank and JPMorgan Chase initiated coverage on the company.

So what: According to Deutsche Bank's covering analyst, Robyn Karnauskas, Wall Street is underestimating the potential of Pharmacyclics, and Johnson & Johnson's blood cancer drug ibrutinib, which is currently under review by the Food and Drug Administration as a new drug applicant. Karnauskas anticipates that ibrutinib will be a transformative drug in the cancer space, and forecasts peak sales of $9 billion, well ahead of the Street's consensus estimate. She placed a $170 price target on the company. JPMorgan, in contrast, didn't release its report to the public, but, according to Investors Business Daily, started coverage with an overweight rating and a $142 price target.

Now what: Absolutely nothing is a certainty in the biotech sector, but ibrutinib is about as close a lock to an FDA approval as you can get. Its results in treating mantle cell lymphoma and chronic lymphocytic leukemia delivered the highest overall response rates ever witnessed in clinical studies for these two diseases, at 68% and 71%, respectively. The sky is the limit for ibrutinib, but I remain concerned that investors have more than baked that optimism into Pharmcyclics' inflated share price.

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The article Why Pharmacyclics Inc. Shares Soared originally appeared on Fool.com.

Fool contributor  Sean Williams has no material interest in any companies mentioned in this article. You can follow him on CAPS under the screen name TMFUltraLong, track every pick he makes under the screen name TrackUltraLong, and check him out on Twitter, where he goes by the handle  @TMFUltraLong . The Motley Fool owns shares of, and recommends Johnson & Johnson. It also owns shares of JPMorgan Chase. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.

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