Oncolytics Presents Promising Phase 1 Data in Colorectal Cancer

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Oncolytics Biotechpresented promising phase 1 data for its cancer drug Reolysin at the ASCO Gastrointestinal Cancers Symposium this weekend.

Reolysin was tested in combination with a cocktail of chemotherapy drugs called FOLFIRI in patients with metastatic colorectal cancer. The drugs produced a progression-free survival -- the amount of time it takes for the disease to progress or the patient to die -- of 7.4 months. Without a control group to compare it to and taking into account that there were only 21 patients in the study, it's difficult to interpret the PFS data.

There was one partial response and nine patients who had stable disease among the 18 patients who were evaluable for response. Most impressive was that some of the patients that responded had previously progressed on irinotecan, the IRI in FOLFIRI.


Oncolytics, in collaboration with the National Cancer Institute of Canada, has already started a phase 2 trial testing Reolysin in combination with Roche's Avastin and a chemotherapy cocktail called FOLFOX compared a control group that will get just FOLFOX and Avastin.

Reolysin is being tested multiple other clinical trials in different tumor types. The most advanced study is in a phase 3 trial in head and neck cancers.

The article Oncolytics Presents Promising Phase 1 Data in Colorectal Cancer originally appeared on Fool.com.

Fool contributor Brian Orelli, Ph.D. and The Motley Fool have no position in any of the stocks mentioned. Try any of our Foolish newsletter services free for 30 days. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.

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