AbbVie's Born -- What Now?

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Abbott Laboratories shares plunged nearly 50% this week. What the heck happened? Relax, it was just the new spinoff AbbVie coming fully to life.

The Abbott name and ticker will remain with the main company, which now limits its focus to generics, nutritional products, diagnostics, and medical devices. AbbVie houses the brand-name pharmaceuticals and biologics. But will those brands support the new company?

Humira reliance
Abbott knows that AbbVie depends on the continued success of its anti-TNF biologic Humira. The drug has nine approved indications and four potentials sitting in late-stage trials. Humira reported sales of $7.9 billion in 2011 and still pulled in double-digit growth last year. But there's a massive step down from Humira to the next best-selling drug.

Here's a look at the leading proprietary drug sales in the nine months that ended the last reported quarter.


Total U.S. Sales (in millions)

YoY Growth (%)

Ex-U.S. Sales (in millions)

YoY Growth (%)




































Niaspan and Tricor face generic competition this year due to patent expirations. HIV drug Kaletra continues to lose ground against competitors. The testosterone replacement treatment AndroGel remains as AbbVie's second best hope right now.

The company needs another strong contender to rise through the pipeline and help Humira out.

The pipeline
AbbVie has a busy pipeline with 10 phase 3 projects and even more in phase 2. Here are the two late-stage standouts I'll watch.

Multiple sclerosis treatment daclizumab, a partnership project with Biogen Idec , should report data sometime next year. Brian Orelli discussed the mid-stage trial results containing promising efficacy better than Teva's  Iaquinimod. But side effect risks presented that included elevated liver enzymes. Daclizumab is a bit behind the pipes of Biogen's oral MS treatment BG-12, which is expected to receive official word from the FDA by spring.

Abbott's next contender belongs to an emerging generation of hepatitis C treatments that don't require a concurrent dose of interferon. The company's oral combination medication is in phase 3 studies and running nearly parallel to Gilead's  sofosbuvir. Both drugs performed well in mid-stage trials, and the phase 3 data could draw a clearer picture of a victor. It will be some time before AbbVie's data reports since the trial was still enrolling at the end of last year.

Foolish final thoughts
It will take time before AbbVie proves its capabilities. Humira continues to perform well, but there's inherent risk in relying on one drug. Watch the company over the course of this next year to see how its pipeline projects pan out.

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The article AbbVie's Born -- What Now? originally appeared on

Fool contributor Brandy Betz has no position in any stocks mentioned. The Motley Fool recommends Gilead Sciences. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.

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